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Pre-Exposure Prophylaxis (PrEP)

Education Packet

Pre-Exposure Prophylaxis (PrEP) – This packet is a compilation of several recent fact sheets and other resources. You may wish to customize it to meet the needs or interests of particular groups, such as event participants, providers, patients, clients, or the general public. So please feel free to distribute all or part of this packet as either a printout or PDF.

Fact Sheets, Infographics, and Brochures

Pre-Exposure Prophylaxis ( – This fact sheet for consumers provides brief, easy-to-read answers to common questions about PrEP, including what PrEP is, why it works, who it is recommended for, what medications are used, and whether it is safe.

Pre-Exposure Prophylaxis (PrEP) (HIVinfo) – This fact sheet includes key points about PrEP, as well as information about what PrEP is and who should consider taking it, PrEP’s safety and efficacy, and what to expect when starting PrEP. Also available in Spanish.

PrEP 101 (CDC) – This illustrated, easy-to-read fact sheet provides basic information about PrEP for consumers. The first page is in English and the second is in Spanish.

PrEP vs. PEP (HIVinfo) – This infographic provides a side-by-side comparison of the differences between PrEP and post-exposure prophylaxis (PEP) for preventing HIV infection. Also available in Spanish.

Prescribe PrEP: Pre-Exposure Prophylaxis FAQs (CDC) – This 8-page brochure for healthcare providers answers frequently asked questions (FAQs) about PrEP. It includes extensive information on what PrEP is, its safety and efficacy, guidelines for prescribing PrEP, what medications are used, recommended health screenings for persons considering or taking PrEP, and several other topics. CDC has also produced a web page for clinicians with an abbreviated version of these PrEP FAQs, together with a section focusing on issues related to providing PrEP during the COVID-19 pandemic.

Is PrEP Right for Me? (CDC) This brochure was developed to support CDC’s HIV prevention campaigns. It answers common questions about PrEP in an infographic format. Also available in Spanish.

PrEP Action Kit (National LGBTQIA+ Health Education Center) – This kit consists of clinical resources to help providers incorporate PrEP into their practices. It includes information on the indications for PrEP, common clinical questions about PrEP, and information on PrEP prescribing and patient management.

PrEP Usage 

Monitoring Selected National HIV Prevention and Care Objectives by Using HIV Surveillance Data United States and 6 Dependent Areas, 2019 (CDC) – This report presents the results of focused analyses of U.S. HIV surveillance data to measure progress toward ending the HIV epidemic. It includes information on the use of PrEP, the stage of HIV disease at time of diagnosis, linkage to HIV medical care, viral suppression, prevalence-based HIV care continuum, HIV deaths and survival, and perinatal HIV infections. 

Guidelines and Recommendations

Final Recommendation Statement: Prevention of Human Immunodeficiency Virus (HIV) Infection: Preexposure Prophylaxis (U.S. Preventive Services Task Force) – This is the Task Force’s most recent guidance on PrEP, including risk assessment of persons who may be candidates for PrEP, medications used for PrEP, adherence, and medical monitoring.

Preexposure Prophylaxis for the Prevention of HIV Infection in the United States – 2017 Update: A Clinical Practice Guideline (U.S. Public Health Service) – This document reviews scientific evidence on the safety and efficacy of daily oral PrEP. It also includes guidance on recommended sexually transmitted disease (STD) screening, hepatitis C testing, and HIV testing for patients being prescribed PrEP.        

Preexposure Prophylaxis for the Prevention of HIV Infection in the United States – 2017 Update: A Clinical Providers’ Supplement (U.S. Public Health Service) – This supplement includes an HIV risk index for assessing persons who inject drugs for PrEP, clinical guidance for transitioning people to PrEP after a course of nonoccupational postexposure prophylaxis (nPEP), and clinical guidance for transitioning people to antiretroviral treatment if they acquire HIV infection while being prescribed PrEP.

Additional Consumer Resources from CDC

CDC’s PrEP Basics (CDC) webpage has links to easy-to-read fact sheets and other resources about PrEP. Topics include:

  • About PrEP
  • PrEP Effectiveness
  • Deciding to Take PrEP
  • Paying for PrEP and associated flow chart
  • Starting and Stopping PrEP
  • Continuing PrEP
  • On-Demand PrEP

CDC’s “Let’s Stop HIV Together” Campaign: Talk PrEP Together page has links to many consumer resources, including a resource finder page that is searchable by format (such as brochures, fact sheets, posters, and videos), language (English or Spanish), target audience (by race/ethnicity, gender, age, or transmission category), and specific topic. As of 2021, there were about 40 PrEP-related resources in English and 20 in Spanish.

PrEP Drug Access Program

Ready, Set, PrEP Program ( –The Department of Health and Human Services’ Ready, Set, PrEP program makes PrEP medications available at no cost for qualifying recipients. Ready, Set, PrEP’s associated page has links for individuals who would like to enroll in the program and for healthcare professionals who would like to enroll their patients.

Selected Resources from AETCs

PrEP and nPEP Essentials for Providers (New England AETC, 2021) - This recording provides essential information about PrEP and nPEP for Providers.

Prescribing PrEP: A Guide for Healthcare Providers (AETC National Coordinating Resource Center – NCRC – and Oregon AETC, 2021) – This pocket reference offers practical guidance on what to consider when prescribing PrEP for patients at risk of HIV infection.

TelePrEP & Tele-STI Care: Optimizing Safer Sex in the Pandemic (New England AETC, 2020) – This webinar discusses what is known about sexual behavior during the COVID-19 pandemic and what constitutes safer sex in the COVID-19 era.

PrEP at Home (New England AETC, 2020) This webinar recording addresses telePrEP and the PrEP at home model for LGBTQIA+ patients.

Prescribing PrEP with Your Organization: A Guide to Starting PrEP in a Clinical Setting – Part 1 and Part 2 (South Central AETC and Prism Health North Texas, 2020) - These are webinar slides from a two-part training on initiating PrEP.

PrEP Assessment Protocol (New England AETC and Yale University, 2020) This protocol is designed to be used as a template for implementing PrEP care into clinical practice.

Long-Acting Injectable Cabotegravir: The Future of HIV PrEP (Mountain West AETC, 2020). This slide set includes an overview of cabotegravir, and provides updates from the Phase III PrEP trial, as well as information on next steps for long-acting PrEP.

TeleHealth for PrEP (New England AETC, 2020). This webinar presentation reviews current studies evaluating PrEP initiation and monitoring via telehealth.

PrEP and Informatics (New England AETC, 2020). This webinar recording includes a discussion on the use of data, electronic health records, and informatics to make informed decisions about PrEP. 

PrEP Training Videos (New England AETC and Fenway Health, 2019) – Series of seven short training videos on different topics related to PrEP, each averaging about 15 to 20 minutes long. Topics include: PrEP and PEP; basic PrEP management; PrEP for serodifferent couples; PrEP and gender diverse communities; PrEP and sexually transmitted infections; PrEP for adolescents; and building programs for PrEP.

Navigating Sexual Health in the Era of PrEP (Southeast AETC, 2019) – This webinar recording and associated slide presentation describe the epidemiology of sexually transmitted infections (STIs) within the context of PrEP, as well as the impact of STIs on HIV prevention.

Prescribing Pre-Exposure Prophylaxis (PrEP) for HIV Prevention: A Guide for Medical Providers (AETC NCRC and Oregon AETC, 2019) – This folding pocket card provides concise information about PrEP indications, contraindications, counseling, efficacy, side effects, lab screening, and related topics.

Southeast Practice Transformation Expansion Project (SEPTEP): An Overview Presentation (Southeast AETC, 2019) – This webinar recording and associated slide presentation provides an overview of the SEPTEP, including information about PrEP.

Common PrEP Questions: A Case-Based Discussion (AETC NCRC and International Antiviral Society-USA, 2019) – This video presentation from the 2019 Ryan White HIV/AIDS Program Clinical Conference uses case discussions to explore common concerns about PrEP.


The contents listed on this page are those of the author(s) and do not necessarily represent the official views of, nor an endorsement by, the New England AIDS Education and Training Center.