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Pre-Exposure Prophylaxis (PrEP)

Education Packet

Pre-Exposure Prophylaxis (PrEP) – This packet is a compilation of recent fact sheets and other resources. You may wish to customize it to meet the needs or interests of particular groups, such as event participants, providers, patients, clients, or the general public. So please feel free to distribute all or part of this packet as either a printout or PDF.


Clinical Resources, Fact Sheets, Infographics, Brochures, and Reports

PrEP Action Kit (New England AETC)
The PrEP Action Kit includes clinical resources to help providers incorporate PrEP into their practices. Including helpful resources such as tips on taking a comprehensive sexual history, frequently asked questions about PrEP and information on PrEP prescribing and monitoring. This action kit is an essential resource for all providers treating LGBTQIA+ patients or patients at risk of HIV infection.

CDC’s Pre-Exposure Prophylaxis (PrEP) webpage has links to easy-to-read fact sheets and other resources about PrEP. Topics include:

Pre-Exposure Prophylaxis ( – This fact sheet for consumers provides brief, easy-to-read answers to common questions about PrEP, including what PrEP is, why it works, who it is recommended for, what medications are used, and whether it is safe, how to get PrEP, and ways to pay for PrEP.

Pre-Exposure Prophylaxis (PrEP) (HIVinfo) – This fact sheet includes key points about PrEP, as well as information about what PrEP is and who should consider taking it, PrEP’s safety and efficacy, and what to expect when starting PrEP. Also available in Spanish.

PrEP 101 (CDC) – This illustrated, easy-to-read fact sheet provides basic information about PrEP for consumers. The first page is in English and the second is in Spanish.

PrEP vs. PEP (HIVinfo) – This infographic provides a side-by-side comparison of the differences between PrEP and post-exposure prophylaxis (PEP) for preventing HIV infection. Also available in Spanish.

Pre-Exposure Prophylaxis: Quick Guide – 2021 PrEP Update (CDC) – This guide summarizes CDC’s 2021 update to Preexposure Prophylaxis for the Prevention of HIV Infection in the United States – A Clinical Practice Guideline. For more information, see a description of the updated guidance in the “Guidelines and Recommendations” section below.

Are You Ready for PrEP? (CDC) – This brochure was developed to support CDC’s HIV prevention campaigns. It answers common questions about PrEP in an infographic format. Also available in Spanish.

CDC’s “Let’s Stop HIV Together” Campaign: PrEP page has links to many consumer resources, including a resource finder page that is searchable by format (such as brochures, flyers, posters, or videos), language (English or Spanish), target audience (race/ethnicity, gender, age, or transmission category), and specific topic.

HIV Infection Risk, Prevention, and Testing Behaviors Among Men Who Have Sex With Men: National HIV Behavioral Surveillance, 13 U.S. Cities, 2021 (CDC) – This report provides descriptive, unweighted about HIV infection among gay, bisexual, and other men who have sex with men (MSM) in 13 major metropolitan statistical areas. It includes information about the percentages of MSM reporting specific behavioral risk factors, HIV testing, and participation in prevention programs. Data are provided about the awareness and use of HIV pre-exposure prophylaxis among men who are not infected with HIV, as well as rates of HIV treatment among men with HIV. 

Expanding the Reach of Pre-Exposure Prophylaxis to End the HIV Epidemic (HRSA CAREAction Newsletter, September 2020) – This issue includes information about the role of PrEP in ending the U.S. HIV epidemic; the Ready, Set, PrEP initiative; as well as two brief case studies of Ryan White HIV/AIDS Program-funded agencies’ efforts to increase the reach of PrEP.

Monitoring Selected National HIV Prevention and Care Objectives by Using HIV Surveillance Data United States and 6 Dependent Areas, 2020 (CDC) – This report presents the results of focused analyses of U.S. HIV surveillance data to measure progress toward ending the HIV epidemic. It includes information on PrEP coverage in the U.S. and Puerto Rico, as well as breakdowns in PrEP use by sex at birth, age, and race/ethnicity (see Tables 8a and 8b).

Delivery of HIV Partner Services in the United States and Dependent Areas, 2020 (CDC) – This report summarizes partner services delivery to over 44,000 index patients who were reported across all U.S. HIV Partner Services programs in 2020. It includes data on HIV test results, linkage to HIV care of partners with a positive HIV test result, and referrals for HIV PrEP for partners with who were HIV-negative.

Telehealth for HIV Care ( – This practice guide  provides information about setting up an HIV telehealth program; discusses the use of telehealth for HIV diagnosis, treatment, and prevention (including PrEP and PEP); and gives guidance on billing for HIV telehealth.

PrEP Access in the United States: The Role of Telehealth (Kaiser Family Foundation) – This issue brief is based on in-depth interviews during late 2021 with representatives from the major national telehealth companies that provide tele-PrEP as well as other selected tele-PrEP programs. It provides an overview of the tele-PrEP landscape, including how various PrEP services are provided, factors that facilitate the provision of tele-PrEP, and the barriers that still limit its use.

Infographics on PrEP Use and Need from AIDSVu

Guidelines and Recommendations

Preexposure Prophylaxis for the Prevention of HIV Infection in the United States – 2021 Update: A Clinical Practice Guideline (U.S. Public Health Service – PHS) – This document provides comprehensive information about the use of PrEP to reduce the risk of acquiring HIV infection, including prescribing PrEP to patients and increasing PrEP use by people who could benefit from it. The 2021 update also includes detailed clinical guidance on the use of cabotegravir extended-release injectable suspension for PrEP, which was approved by the U.S. Food and Drug Administration in December 2021.

Preexposure Prophylaxis for the Prevention of HIV Infection in the United States – 2021 Update: A Clinical Providers’ Supplement (PHS) – This supplement to the PHS PrEP Clinical Practice Guidelines provides additional materials, including a patient/provider checklist, information sheets, risk indexes and guidance, and other tools that may be useful to clinicians providing PrEP.


PrEP Drug Access Program

Ready, Set, PrEP ( – The Department of Health and Human Services’ Ready, Set, PrEP program makes PrEP medications available at no cost for qualifying recipients. An associated enrollment page has specific information about the Ready, Set, PrEP’s eligibility requirements and how to join the program.


Selected Resources from AIDS Education and Training Centers (AETCs)

PrEP Update: What Clinicians Need to Know (New England AETC, June 2022) – This webinar provides an update on PrEP for new health staff.

New PrEP Guidelines (New England AETC, May 2022) – This webinar provides updated guidance related to PrEP informed by new PrEP guidelines and FDA’s recent approval of injectable PrEP.

PrEP for PWID: Challenges and Opportunities (Mountain West AETC, May 2022) – This training reviews challenges (lack of awareness, interest, and risk perception), and opportunities (improving uptake, sustainability, and adherence) for PrEP use among people with injection drug use disorder.

Long-Acting Injectable HIV Treatment and PrEP (New England AETC, March 2022) – This webinar provides information about new long-acting HIV injectable cabotegravir for PrEP and cabotegravir/rilpivirine for treatment.

PrEP for HIV Prevention: The 4-1-1 on 2-1-1 (Mountain West AETC, March 2022) – These training slides provide a review of real-world PrEP data and explain why people choose the 2-1-1 prescribing schedule.

PrEP for HIV (Southeast AETC, March 2022) – These training slides review the background and importance of PrEP (with particular emphasis on the U.S. Southeast) and identify provider and patient barriers to PrEP, PrEP eligibility, prescribing, counseling, adverse effects, and lab monitoring.

HIV Treatment Guidelines and PrEP (New England AETC, January 2022) – This webinar provides updates on CDC/DHSS HIV clinical guidelines on HIV testing; antiretroviral treatment, including treatment options when virologic failure occurs; linkage to care, and PrEP.

PrEP for Prevention of HIV in the U.S., 2021 Update (Mountain West AETC, December 2021) – These training slides include information about the use of injectable cabotegravir for PrEP.

PrEP Your Step (New England AETC, December 2021) – This podcast covers: 1) the role of social determinants of health in the use of PrEP; 2) the importance of neighborhood factors and social environments in HIV-related health disparities; and 3) the importance of collaborating with target audiences when developing messaging aimed at ending the HIV epidemic.

Dapivirine Ring for HIV PrEP (Mountain West AETC, November 2021) – These training slides describe the safety and efficacy of the dapivirine vaginal ring for sustained delivery of ARV drugs.

PrEP Infographic (Northeast/Caribbean AETC and others, August 2021) – This infographic is designed for providers to help increase patient awareness and understanding of PrEP.

PrEP Screening Pocket Guide (Pacific AETC and others, August 2021) – This downloadable pocket guide includes information about PrEP indications, contraindications/cautions, required testing, prescriptions and dosages, side effects, efficacy, counseling, monitoring, billing codes, medication assistance, and resources for further information.

PrEP to Prevent HIV Acquisition (Northeast/Caribbean AETC, August 2021) – This is a comprehensive package of recommendations and practical tools for clinicians to support provision of PrEP, with particular emphasis on New York State.

A Hard Pill to Swallow: Understanding Black MSM and their Relationship to PrEP (Midwest AETC, July 2021) – These training materials review the impact of HIV among Black men who have sex with men (BMSM), discuss perceptions about BMSM and PrEP uptake, and identify strategies for recruiting and engaging BMSM with PrEP.

TelePrEP: Telemedicine for HIV Prevention  (New England AETC, June 2021) – This publication discusses the advantages and challenges of telePrEP, the use of telemedicine for pre-exposure prophylaxis (PrEP), and best practices for clinicians and PrEP programs.


Selected Recent Reports from CDC’s Morbidity and Mortality Weekly Report

Each of these recent reports includes information about PrEP awareness or use in the United States.

HIV Services and Outcomes During the COVID-19 Pandemic – United States, 2019-2021

HIV Testing Before and During the COVID-19 Pandemic – United States, 2019-2020

Factors Associated with Use of HIV Prevention and Health Care Among Transgender Women – Seven Urban Areas, 2019-2020

Vital Signs: HIV Infection, Diagnosis, Treatment, and Prevention Among Gay, Bisexual, and Other Men Who Have Sex with Men – United States, 2010-2019

Racial, Ethnic, and Gender Disparities in Awareness of Preexposure Prophylaxis Among HIV-Negative Heterosexually Active Adults at Increased Risk for HIV Infection – 23 Urban Areas, United States, 2019

HIV Preexposure Prophylaxis Awareness and Referral to Providers Among Hispanic/Latino Persons – United States, 2019


The contents listed on this page are those of the author(s) and do not necessarily represent the official views of, nor an endorsement by, the New England AIDS Education and Training Center.