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Post-Exposure Prophylaxis (PEP)

Education Packet

Post-Exposure Prophylaxis (PEP) – This packet is a compilation of recent fact sheets and other resources. You may wish to customize it to meet the needs or interests of particular groups, such as event participants, providers, patients, clients, or the general public. So please feel free to distribute all or part of this packet as either a printout or PDF.


Fact Sheets, Infographics, and Brochures

Post-Exposure Prophylaxis (PEP) (HIVinfo) – This resource includes key facts about PEP, as well as information about what PEP is and who should consider taking it, when PEP should be started after a possible exposure to HIV, what medicines are used for PEP, how effective PEP is in preventing HIV transmission, and potential side effects from PEP. Also available in Spanish.

PEP 101 (CDC) – This illustrated, easy-to-read fact sheet provides basic information about PEP for consumers. The first page is in English and the second is in Spanish.

PEP (Post-Exposure Prophylaxis) (CDC) – This web page provides a brief description of PEP and links to three easy-to-read CDC fact sheets: About PEP, Paying for PEP, and PEP and Workplace Exposures. Also available in Spanish.

PrEP vs. PEP (HIVinfo) – This infographic provides a side-by-side comparison of the differences between pre-exposure prophylaxis (PrEP) and PEP for preventing HIV infection. Also available in Spanish.

Post-Exposure Prophylaxis (CDC) – This web page for providers answers frequently asked questions about PEP, including questions about prescribing guidelines, the types of exposure that warrant PEP, who can prescribe PEP, recommended PEP regimens, PEP safety, baseline assessments that are performed before starting PEP, patient support, and insurance issues.

Do You Know About PEP? (CDC) – This brochure was developed to support CDC’s HIV prevention campaigns. It answers common questions about PEP in an infographic format.

Telehealth for HIV Care ( – This practice guide  provides information about setting up an HIV telehealth program; discusses the use of telehealth for HIV diagnosis, treatment, and prevention (including PEP and PrEP); and gives guidance on billing for HIV telehealth.


Guidelines and Recommendations

Updated Guidelines for Antiretroviral Postexposure Prophylaxis After Sexual, Injection Drug Use, or Other Nonoccupational Exposure to HIV – United States, 2016 (CDC) – This document includes guidance on evaluating people seeking care after a possible exposure to HIV, recommended lab tests to be performed before prescribing PEP, recommended drug regimens for PEP, and additional considerations, such as providing adherence support and HIV prevention counseling. 

Updated U.S. Public Health Service Guidelines for the Management of Occupational Exposures to HBV, HCV, and HIV and Recommendations for Postexposure Prophylaxis – Updated during 2018, this is the USPHS’s PEP guidance for occupational exposures to HIV and viral hepatitis. It emphasizes the importance of primary prevention strategies, prompt reporting and management of occupational exposures, adherence to recommended PEP regimens, and careful monitoring for treatment side effects and any signs of HIV infection.    

Selected Resources from AIDS Education and Training Centers (AETCs)

18th Annual Conference on HIV/AIDS & Aging (New England AETC, September 2022) – This webinar covers many issues related to HIV and aging, including PEP, PrEP, long-term survival, primary prevention, transgender health, oral health, mental health, and substance use.

Non-Occupational Post-Exposure Prophylaxis (nPEP) Toolkit (AETC National Coordinating Resource Center, January 2022) – This toolkit includes an nPEP quick guide, a flyer, a poster on prescribing nPEP, and a medication assistance quick guide that includes programs that help pay for PEP.

nPEP Myths and Facts (AETC National Coordinating Resource Center, January 2022) – This flyer dispels common myths and provides key facts about non-occupational post-exposure prophylaxis (nPEP).

nPEP Quick Guide for Providers (AETC National Coordinating Resource Center, November 2021) – This guide provides assessment, treatment, and follow-up recommendations for people with known or potential exposures to HIV and other infections.

PrEP-ing Native Communities (Midwest AETC and others, April 2021) – These training slides focus on how to start a PrEP program in clinical settings that serve Native communities, but they also include information about PEP. Topics include: the difference between PEP and PrEP; how to communicate with patients about PrEP and PEP; how to initiate PrEP; and finding resources to support clients.


The contents listed on this page are those of the author(s) and do not necessarily represent the official views of, nor an endorsement by, the New England AIDS Education and Training Center.