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Post-Exposure Prophylaxis (PEP)

Education Packet

Post-Exposure Prophylaxis (PEP) – This packet is a compilation of several recent fact sheets and other resources. You may wish to customize it to meet the needs or interests of particular groups, such as event participants, providers, patients, clients, or the general public. So please feel free to distribute all or part of this packet as either a printout or PDF.

Fact Sheets, Infographics, and Brochures

Post-Exposure Prophylaxis (PEP) (HIVinfo) – This fact sheet includes key facts about PEP, as well as information about what PEP is and who should consider taking it, when PEP should be started after a possible exposure to HIV, what medicines are used for PEP, how effective PEP is in preventing HIV transmission, and potential side effects from PEP. Also available in Spanish.

PEP 101 (CDC) – This illustrated, easy-to-read fact sheet provides basic facts about PEP for consumers. The first page is in English, and the second is in Spanish.

PEP (Post-Exposure Prophylaxis) (CDC) – This web page provides a brief description of PEP, and links to three easy-to-read CDC fact sheets:

PEP (Profilaxis Posexposición) (CDC) – This fact sheet provides extensive information about PEP in frequently asked question (FAQ) format for Spanish-speaking consumers and providers.

PrEP vs. PEP (HIVinfo) – This infographic provides a side-by-side comparison of the differences between pre-exposure prophylaxis (PrEP) and PEP for preventing HIV infection. Also available in Spanish.

Prescribe PEP: Post-Exposure Prophylaxis FAQs (CDC) – This 8-page brochure for healthcare providers answers frequently asked questions about PEP, as well as providing extensive information on evidence supporting the safety and efficacy of PEP, when it is appropriate to prescribe PEP, what medications are used, insurance coverage, and several other topics. CDC has also produced a web page for clinicians with an abbreviated version of these PEP FAQs.

Do You Know About PEP? (CDC) This brochure was developed to support CDC’s HIV prevention campaigns. It answers common questions about PEP in an infographic format.

Guidelines and Recommendations

Updated Guidelines for Antiretroviral Postexposure Prophylaxis After Sexual, Injection Drug Use, or Other Nonoccupational Exposure to HIV – United States, 2016 (CDC) – These are the most recent U.S. guidelines on PEP use. These include guidance on evaluating people seeking care after a possible exposure to HIV, recommended lab tests to be performed before prescribing PEP, recommended drug regimens for PEP, and additional considerations, such as providing adherence support and HIV prevention counseling. 

Interim Statement Regarding Potential Fetal Harm from Exposure to Dolutegravir – Implications for HIV Post-Exposure Prophylaxis (CDC) – This document provides guidance cautioning against the use of PEP regimens that contain the antiretroviral drug dolutegravir for women in the early weeks of pregnancy and for nonpregnant women of childbearing potential who are not using an effective birth control method.

Updated U.S. Public Health Service Guidelines for the Management of Occupational Exposures to HBV, HCV, and HIV and Recommendations for Postexposure Prophylaxis – Published during 2013 in the journal Infection Control and Hospital Epidemiology, this is the USPHS’s most recent PEP guidance for occupational exposures to HIV and viral hepatitis.  

Selected Resources from AETCs

Non-Occupational Post-Exposure Prophylaxis (nPEP) Toolkit (AETC National Coordinating Resource Center – NCRC, 2019): The following toolkit materials were developed for use in clinical settings to raise awareness and offer detailed guidance:

  • nPEP Pocket Guide for Providers
  • nPEP Infographic Slides
  • nPEP Poster
  • PEP Medication Assistance Program Postcard
  • nPEP Post-Sexual Exposure Policy & Procedures Template
  • nPEP Post-IDU Exposure Policy & Procedures Template
  • IDU Naloxone Educational Information
  • nPEP Prescribing Myths

PrEP and nPEP Essentials for Providers (New England AETC, 2021) – This recording provides essential information about PrEP and nPEP for providers.

Does this Patient Need PEP? (Mountain West AETC, 2021) – These slides from a case-based training review three scenarios of possible HIV exposures to assess when prescribing PEP is appropriate.

nPEP Post-Sexual Exposure (AETC NCRC, 2020) – This is an assessment algorithm for post-sexual exposures to HIV.

PEP Medication Assistance Programs (AETC NCRC, 2020) – This is an annotated list of PEP medication assistance programs sponsored by drug manufacturers and patient advocacy groups.

HIV Non-Occupational Post-Exposure Prophylaxis (nPEP) and Processes of Patient Care (Mountain West AETC, 2020) – These are webinar slides from a Mountain West AETC ECHO training on HIV nPEP processes for patient care.

Non-Occupational Post-Exposure Prophylaxis (nPEP) in Rural Areas – Does It Exist? (ShareSpot, 2018) – This brief article was published on the AETC Blog.

Sexual Assault: PEP is an Urgent Health Need (ShareSpot, 2018) – This brief article was published on the AETC Blog.

HIV Essentials and Quick Clinical Guides (Pacific AETC, 2018) – This document is a compilation of some of the Pacific AETC’s most popular clinical reference guides.  The fifth guide in the document is the “PEP (Post-Exposure Prophylaxis) Quick Clinical Guide.”

Prescribing nPEP Infographics (AETC NCRC, 2018) – These infographics provide background information and recommendations for prescribing non-occupational post-exposure prophylaxis at rural healthcare facilities in the U.S.


The contents listed on this page are those of the author(s) and do not necessarily represent the official views of, nor an endorsement by, the New England AIDS Education and Training Center.