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HIV and Hepatitis C Co-infection

Education Packet 

HIV and Hepatitis C Co-infection – This packet is a compilation of several recent fact sheets and other resources. You may wish to customize it to meet the needs or interests of particular groups, such as event participants, providers, patients, clients, or the general public. So please feel free to distribute all or part of this packet as either a printout or PDF.

Fact Sheets, Infographics, and Briefs 

HIV and Coinfection: HIV and Viral Hepatitis (CDC) – The first section of this fact sheet provides an overview of hepatitis A (HAV), hepatitis B (HBV), and hepatitis C (HCV), followed by a discussion of co-infections involving HIV and viral hepatitis. It also includes a discussion of the risk factors for and prevalence of these coinfections in the U.S., and the prevention, testing, and treatment of viral hepatitis. 

HIV and Hepatitis C (HIVinfo) – This fact sheet describes what HCV is, how it is transmitted, the connection between HIV and HCV, and HCV prevention, testing, symptoms, and treatment.  Also available in Spanish 

HIV and Hepatitis B and Hepatitis C Coinfection ( – This web page in question-and-answer format includes information on hepatitis B and C transmission, prevention, and treatment, as well as recommended hepatitis testing for people with HIV. 

People Coinfected with HIV and Viral Hepatitis (CDC) – This brief begins with a section about the importance of vaccinations for HAV and HBV for persons with HIV, as well as testing for HBV and HCV. It also discusses the transmission, prevalence, and health risks associated with co-infections involving HIV and viral hepatitis. Links to guidelines and recommendations for the management of HIV and viral hepatitis co-infection are also provided, together with links to additional resources on co-infection. 

Barriers to Curing Hepatitis C Virus Among Coinfected People with HIV (AETC National Coordinating Resource Center) – According to AETC, this infographic “addresses some of the barriers to curing HCV infection among co-infected people with HIV. It highlights provider, patient, and financial/systems barriers, provides information for HCV treatment initiation based on the latest treatment guidelines, and offers additional considerations to help health professionals navigate through some of the challenges outlined.” 

Guidelines and Recommendations 

Considerations for Antiretroviral Use in Patients with Coinfections ( – This section of the Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV includes recommendations for screening people living with HIV for HCV; providing antiretroviral therapy (ART) for HIV to co-infected persons; the potential for liver toxicity among co-infected persons receiving ART; and concurrent treatment of HIV and HCV.  

Patients with HIV/HCV Coinfection (American Association for the Study of Liver Diseases and Infectious Diseases Society of America) – This is a section of HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C. It includes tables of recommendations on managing interactions of the drugs used to treat HCV and HIV, as well as guidance regarding regimens not recommended for persons with HIV/HCV co-infection.

Curricula, Toolkits, and Other Educational Materials 

HIV/HCV Co-infection: An AETC National Curriculum (AETC) – This curriculum for healthcare providers and trainers of healthcare providers is designed “to increase their knowledge on HIV and HCV co-infection among people of color in the United States and its territories,” according to AETC. The curriculum has the following six core modules: epidemiology; prevention; screening, testing, and diagnosis; HCV treatment; recommendations for subpopulations of HIV/HCV co-infected persons; and addressing barriers for co-infected people of color. 

Treatment of HCV in Persons with HIV Coinfection (University of Washington) – This self-study module provides background on HIV/HCV co-infection, a review of data on HCV treatment in people with HIV, recommended HCV treatment in persons with HIV co-infection, treatment of HIV in persons with HCV co-infection, drug interactions with HIV/HCV co-infection treatment, a summary of key points, and an extensive reference list. 

HIV and HCV Drug Interactions: Quick Guides for Clinicians (Northeast/Caribbean AETC) – This is a collection of clinical guides concerned with drug interactions involving antiretroviral drugs, HCV direct-acting antivirals (DAAs), and other common medications used in primary care. 

Hepatitis C Prescriber Toolkit (TargetHIV, HRSA) – This toolkit has state-specific resources to help providers navigate the health coverage requirements that affect the prescription of HCV treatment. It includes information about prescribing restrictions; Ryan White HIV/AIDS Program AIDS Drug Assistance Program coverage; and Medicare coverage.  

CROI 2021 Update: HIV Co-infections and Comorbidities (Mountain West AETC) - These training slides review various studies on HIV co-infecions involving hepatitis C, COVID-19, and tuberculosis.

Ending the HIV & HCV Epidemics: A Critical Role for Substance Use Providers (National Alliance for HIV Education and Workforce Development): “This slide set introduces substance use disorder providers to the issues of HIV and HCV screening and prevention, recognizing the important role that substance use disorder providers play in these areas,” according to AETC. 

Viral Hepatitis in People with HIV: A Case-Based Primer (Southeast AETC) – This recorded webinar from 2019 covers key topics including HBV and HCV treatment eligibility, drug-drug interactions, and hepatocellular carcinoma screening in people with HIV. 

The Ryan White Program Opiate Epidemic Response in WV (Southeast AETC) – This recorded webinar discusses outbreaks of HIV and HCV infection in southern West Virginia; describes strategies to reduce the harm associated with injection drug use in comprehensive outpatient HIV care clinics; and identifies the challenges associated with implementation of community-based public health syringe services programs in rural areas.


The contents listed on this page are those of the author(s) and do not necessarily represent the official views of, nor an endorsement by, the New England AIDS Education and Training Center.